Kyambura Game Reserve or Chambura Game Reserve, which borders to the west of Kyambura gorge, is part of the Queen Elizabeth National Park (QENP) in Uganda. It is home to a variety of wildlife. The area is an important water source for many animals and is surrounded by savanna, but is generally noted for its high concentration of primate life located in the gorge.

Kyambura  Game Reserve was formed to serve as a buffer zone to the Queen Elizabeth national park. It is located on north-eastern side of QENP, approximately 30 km from Queen Elizabeth National Park headquarters. Kyambura gorge spans a distance of 11 km and links to the Kazinga channel, which forms the northern boundary of the reserve. Village and plantations lie to the south.

A total of 13 habitats have been recorded in the reserve. Kyambura is the only place in Queen Elizabeth National Park where habituated chimpanzees and other types of primates including red-tailed monkey, black and white colobus, baboons and vervet monkeys are seen. The park is also known for its variety of avian species including various falcons, the blue-headed bee-eater and the African finfoot.