The Katonga wildlife reserve is a wildlife reserve in western Uganda, along the banks of the Katonga river. The reserve was established in 1998 and has approximately 211 square kilometers (81 sq mi). Many of the species of plants and animals in the reserve are unique to its wetland environment.

The reserve is named after the Katonga river, which flows from Lake Victoria in the east to Lake George in the west.

The reserve is located in the Ibanda and Kamwenge districts in western Uganda. In Kamwenge, it borders with the Biguli sub-county in Kyenjojo district. The reserve is approximately 200 kilometers (120mi), by road, west of Kampala, Uganda’s capital city. The coordinates of the wildlife reserve are 00 02N, 30 25E.

The vegetation of the reserve is mixed savannah with acacia scrubland or woodlands. A large portion of the reserve is either permanent or seasonal wetlands. There are also a number of riverine and tropical forests.

There are over forty animal species and over 150 bird species within the reserve. The wildlife species within the reserve include Sitatunga, Reedbuck, Waterbuck, Warthog, Bushbuck, Colobus monkeys, Elephants and Otter.