The Sezibwa River is a river in central Uganda, in East Africa. The name is derived from the Luganda phrase “sizibwa kkubo”, which translates in “my path cannot be blocked”.

River Sezibwa is located in the southern central part of Uganda. It starts from the wetlands between Lake Victoria and Lake Kyoga, west of the Victoria Nile and flows in a general northerly direction to empty into Lake Kyoga. The source of river sezibwa is located in buikwe district, near the town of ngogwe, with river sezibwa is approximately 150 kilometers (93 mi) from source to end. Between its source in buikwe district, but before it enters Kayunga district, the river flows through Mukono district.